Growth hormone secretagogue receptorghs r also known as ghrelin receptor is a g protein coupled receptor that binds growth hormone secretagogues ghss such as ghrelin the hunger hormone the role of ghs r is thought to be in regulating energy homeostasis and body weight in the brain they are most highly expressed in the hypothalamus specifically the ventromedial nucleus and arcuate . Growth hormone releasing hormone and growth hormone secretagogues growth hormone secretagogues such as ghrh ghrelin and their mimetics stimulate the secretion of gh if the pituitary is intact and responsive since most aghd is due to hypopituitarism and these patients . Growth hormone secretagogues or gh secretagogues ghss are a class of drugs which act as secretagogues ie induce the secretion of growth hormone gh they include agonists of the ghrelin growth hormone secretagogue receptor ghsr such as ghrelin lenomorelin pralmorelin ghrp 2 ghrp 6 examorelin hexarelin ipamorelin and ibutamoren mk 677 and agonists of the growth hormone . Growth hormone produced in the pituitary gland is one of the bodys three major anabolic hormones the others are testosterone and insulin a peptide hormone meaning that its composed of a long chain of amino acids in a specific sequence supplemental growth hormone must be administered by injection. Growth hormone secretagogue products are not typically used by themselves but combined with other products including cardarine to enhance metabolism improve endurance and promote energy growth hormone secretagogues like mk 677 are also combined with other selective androgen receptor modulators sarms such as andarine for fat loss
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